Director of Office of the CEO (Founder in Residence)

Join BillionToOne, a pioneering company in molecular diagnostics, as the Director of the Office of the CEO. In this high-impact role, you will work directly with the CEO and Chief of Staff on strategic and operational projects, leading cross-functional teams and driving results in a fast-paced environment. This is a hybrid position based in the SF Bay Area, with a focus on innovation and making a difference in the lives of patients.

• Lead and manage high-priority strategic and operational initiatives sourced directly from the CEO and Office of the CEO, including new product launches and commercial strategies.
• Identify under-performing processes and workflows, diagnose root causes, design solutions, and drive execution end-to-end with cross-functional teams.
• Participate in CEO meetings, present to the executive team, and serve as a trusted thought partner to the CEO and Chief of Staff on company-shaping decisions.
• The ideal candidate is a first-principles thinker, a builder, AI-native, and exceptionally sharp. You have founded a company, operated at the most senior level of a top scaleup, or built a track record of high-impact strategic work, and you are looking for your next high-leverage seat — one that gives you scale, mission, and direct CEO exposure without starting from scratch
• One of the following backgrounds: founder of a company that has since been acquired, wound down, or moved on from; senior executive (COO, CPO, VP-level) who joined a top scaleup as one of its first 5 to 10 employees; or top-tier management consultant from MBB or a top boutique firm with healthcare or life sciences exposure, with some operational experience under your belt
• 6-10+ years of building or operating experience, with a track record of exceptional impact in entrepreneurial or builder-oriented environments
• Strong written and verbal communication, including with executives and the Board
• AI-native fluency in using AI tools to move faster and amplify individual leverage
• On-site position (relocation to SF Bay Area required)
• Builder mentality — bias to action, comfort with ambiguity, ability to operate without a playbook
• First-principles thinker with exceptional analytical horsepower
• Genuine interest in molecular diagnostics and the BillionToOne mission
• Track record of building 0 to 1 — new products, new functions, new business lines, or new operating mechanisms
• Prior exposure to healthcare, life sciences, molecular diagnostics, or other regulated industries
• Existing network in the founder community, YC ecosystem, or top scaleup operating community