Senior Scientist - CRISPR & Functional Genomics

**Recruitment steps**

1. **Introduction call (20min)** – An initial discussion to better understand your background, experiences, and motivations.
2. **Technical Interview (45min)** – A deep dive into your technical skills and expertise relevant to the role.
3. **Case Interview (1h)** – A case study or problem-solving exercise to assess your strategic thinking and analytical abilities. In-person when possible to meet the team.

• **Reference calls** - 2-3 references including at least a direct manager.

1. **Culture Fit Interview (45min)** – A conversation with our team to ensure alignment with our company culture, values, and ways of working.

• Design and execute gene-perturbation and drug screens in patient-derived tumor organoids.
• Build and enhance Orakl's CRISPR and functional genomics capabilities, including gRNA design and KO validation.
• Independently plan, prioritize, and execute complex experimental pipelines with high quality and reproducibility.

**Preferred Experience**
### **Must have**

• PhD in molecular biology, cancer biology, biotechnology, or related field, ~1–5 years industry experience would be a plus.
• Proven proficiency with CRISPR gene editing in mammalian systems (ideally in organoids): gRNA design, MOI optimization, KO validation.
• Experience with both lentiviral-based and electroporation-based is preferred.
• Hands-on expertise in organoid culture.
• Knowledge of molecular biology techniques (RT PCR, qPCR/ddPCR, Western Blot, DNA and RNA isolation etc.) and flow cytometry/FACS.
• Exceptional wet-lab fundamentals: sterile technique, routine culture, molecular biology, cloning, assay development, QC.
• Demonstrated ability to independently plan, prioritize, and execute complex experimental pipelines with high quality and reproducibility.
• Strong analytical, quantitative data interpretation, and clear documentation/reporting skills.

### **Nice to have**

• Experience with pooled/arrayed CRISPR screens or other functional genomics approaches.
• Experience with drug-response profiling in organoids (dose–response, time-course, combination assays) and high-throughput screening.
• Knowledge of programming e.g. Python
• Previous responsibility for managing CROs or academic collaborations.
• Experience mentoring junior scientists, lab technicians and/or establishing lab standards.
• Prior involvement in early-stage drug discovery or cross-functional oncology research.

**What will you find at Orakl**

• Mission: Work in a cutting-edge environment, on the bleeding edge of cancer research.
• Growth opportunities: we’re rapidly expanding the scope of our work and you will be offered multiple opportunities to grow with it!
• Impact: you’re going to be participating in a fast-growing, multi-faceted project with multiple opportunities to shape it according to your interests.
• More about Orakl [on our Welcome to the Jungle page](https://www.welcometothejungle.com/fr/companies/orakl-oncology) and [on our website](https://www.orakl-oncology.com)