Postdoctoral Position - HIV 1 Innate Sensing (F/M)

Join the SCInflaNet laboratory at Institut Imagine, led by Dr. Mickaël Ménager. This postdoctoral position focuses on the molecular mechanisms controlling inflammatory responses, specifically the link between HIV-1 infection, lipid metabolism, and type I interferon production in dendritic cells. The successful candidate will employ cutting-edge approaches, including lipidomics, scRNA-seq, scATAC-seq, and systems biology. The position offers a vibrant research environment, access to world-class technological platforms, strong mentoring and career development opportunities, and a competitive salary.

• Caractériser les altérations induites par le VIH-1 dans le métabolisme lipidique et les voies de signalisation médiées par les lipides dans les cellules dendritiques humaines.
• Investiguer comment le métabolisme lipidique influence la réplication du VIH-1, les mécanismes de détection virale innée et les réponses des interférons de type I.
• Utiliser des approches de pointe, y compris la lipidomique, le séquençage à cellule unique, et les analyses de systèmes biologiques.

### Required qualifications

• PhD in Immunology, Virology, Cell Biology, Molecular Biology, or a closely related field.
• Strong publication record relative to career stage.
• Experience with primary human immune cell culture (e.g., dendritic cells, macrophages, PBMCs).
• Expertise in molecular and cellular biology techniques such as:
• Flow cytometry,
• qPCR,
• Western blotting,
• CRISPR-based approaches.
• Excellent written and spoken English.
• Ability to work independently while contributing to a collaborative team environment.

### Desired qualifications

• Experience in HIV-1 or retrovirology research.
• Experience working in BSL-3 environments.
• Knowledge of lipid metabolism and/or lipidomics.
• Experience with single-cell omics technologies.
• Computational and bioinformatics skills (R, Python, Seurat, Scanpy).

### Application procedure

Applicants should submit a single PDF containing

• Cover letter (maximum 1 page) describing motivation and suitability for the position.
• Curriculum Vitae including publication list.
• Research summary (maximum 1 page).
• Contact information for 2–3 referees (or reference letters).