Postdoctoral Position - SMART JIA Project (F/M)

Join the Ménager lab at the Institut Imagine in Paris as a postdoctoral researcher for the SMART-JIA project. This project focuses on validating and characterizing predictive biomarkers of anti-TNF non-response in Juvenile Idiopathic Arthritis and adult Rheumatoid Arthritis. You will design and analyze single-cell multi-omics experiments, develop functional assays, and contribute to biomarker validation. The position offers a competitive salary, opportunities for career development, and the chance to live and work in one of Europe's leading scientific hubs.

• Design, perform, and analyze single-cell multi-omics experiments (10x Genomics Multiome, scRNA-seq, scATAC-seq) from patient-derived PBMCs.
• Develop and execute ex vivo functional assays to investigate molecular mechanisms of treatment resistance.
• Contribute to biomarker validation and development of the SMART-Score predictive algorithm with clinical collaborators.

### Required qualifications

• PhD in Immunology, Cell Biology, Molecular Biology, or a related discipline
• Strong expertise in flow cytometry/cell sorting and functional immunology assays
• Experience with primary human immune cells, ideally from clinical cohorts
• Familiarity with single-cell omics technologies (10x Genomics) and/or epigenetic approaches
• Ability to work independently in a collaborative, translational research environment
• Excellent scientific communication skills (written and oral, in English)

### Preferred qualifications

• Experience in autoimmunity, or inflammatory/rheumatic diseases
• Computational skills in R/Python for single-cell data analysis
• Track record of publication in peer-reviewed journals

### **How to apply :**

Applicants should submit a single PDF containing

• Cover letter (maximum 1 page) describing motivation and suitability for the position.
• Curriculum Vitae including publication list.
• Research summary (maximum 1 page).
• Contact information for 2–3 referees (or reference letters).