PhD Student Infection Biology and Field Assisted Biofabrication (ID 2105)

Short Description Fracture-related infection (FRI) remains one of the most challenging complications in orthopaedic trauma, frequently resulting in bone destruction, implant failure, and prolonged treatment. Recent evidence suggests that early infection-induced bone loss is primarily driven by neutrophil-mediated inflammation and proteolytic degradation, alongside classical osteoclast-driven pathways. This project (DONUT – Development of advanced Osteolysis Model drive by NeUTrophils) aims to further our knowledge on this topic by developing a novel human-relevant 3D in vitro model that integrates: Spatially organized bone constructs generated using Sound-Induced Morphogenesis Integration of immune cell populations including neutrophils Controlled introduction of Staphylococcus aureus Advanced molecular and imaging-based readouts The project will enable mechanistic insights into infection-induced osteolysis and provide a platform for testing new therapeutic strategies. Start of work: Position will remain open until role is filled, preferred start by October 2026. Duration: 4 years Main Responsibilities Develop and optimise 3D biofabricated bone model with immune cells Establish infection models with Staphylococcus aureus Introduce and study neutrophil-driven inflammatory processes Apply advanced analytical techniques (e.g. imaging, transcriptomics, cytokine profiling) Analyse and interpret experimental data Contribute to scientific publications and presentations Main Requirements Master’s degree in biomedical engineering, biology, microbiology, or a related field Experience in cell culture and laboratory techniques (e.g. molecular biology, microscopy, microbiology) Experience in neutrophil handling and culture Experience in planning and executing research experiments Strong interest in infection biology, immunology, and/or biomaterials Excellent communication skills in English Ability to work independently as well as collaboratively in an interdisciplinary environment High motivation and enthusiasm for research Additional desirable skills: Experience with 3D cell culture or tissue models Knowledge of host–pathogen interactions or infection models Familiarity with biofabrication, hydrogels, or biomaterials Exposure to advanced imaging or omics approaches